EFFECTIVENESS OF THE COMBINATION OF BINAHONG LEAF EXTRACT (Anredera Cordifolia (TEN.) Steenis) AND ORANGE PEEL EXTRACT (Citrus Nobilis L.) ON BLOOD GLUCOSE LEVELS IN RATS

Mexsi Mutia Rissa; Fitria Dhirisma; Qarriy Aina Urfiyya

doi:10.51771/fj.v5i2.1402

Authors

Mexsi Mutia Rissa Akademi Farmasi Indonesia Yogyakarta
Fitria Dhirisma Akademi Farmasi Indonesia Yogyakarta
Qarriy Aina Urfiyya Akademi Farmasi Indonesia Yogyakarta

DOI:

https://doi.org/10.51771/fj.v5i2.1402

Keywords:

Diabetes mellitus, Anredera cordifolia, Citrus cobilis, Streptozotocin

Abstract

Diabetes mellitus is a lifelong disease that requires continuous treatment. However, the long-term use of antidiabetic drugs may cause side effects, thereby encouraging the search for alternative therapies using traditional medicinal plants such as binahong (Anredera cordifolia (Ten.) Steenis), which contains flavonoids and saponins, and tangerine peel (Citrus nobilis L.). These compounds are known to possess blood glucose-lowering properties. This study aimed to determine the antidiabetic effect of ethanol extract of binahong leaves in rats (Rattus norvegicus) induced with streptozotocin.This research was an experimental study using a pre- and post-test with controlled group design, involving 25 rats divided into five groups: negative control, positive control (glibenclamide), treatment with binahong leaf ethanol extract, treatment with tangerine peel ethanol extract, and treatment with a combination of both extracts.The results showed that binahong leaf extract (24.5 mg/KgBW) and tangerine peel extract (150 mg/KgBW) effectively reduced blood glucose levels in rats. The combination of both extracts at doses of 12.25 mg/KgBW and 75 mg/KgBW, respectively (50:50 ratio), was the most effective in lowering blood glucose levels. The combination of ethanol extracts of binahong leaves and tangerine peel can be used as a potential alternative therapy for diabetes mellitus in streptozotocin-induced rats.

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