MULTI-TARGET ACTIVITY OF BIOACTIVE COMPOUNDS FROM Saurauia vulcani LEAVES IN DIABETES AND OBESITY: AN IN SILICO STUDY
AKTIVITAS MULTI-TARGET SENYAWA AKTIF DAUN Saurauia vulcani pada DIABETES DAN OBESITAS: STUDI IN SILICO
DOI:
https://doi.org/10.51771/fj.v6i02.2319Keywords:
Saurauia vulcani, pirdot leaves, diabetes mellitus, obesity, network pharmacology, molecular dockingAbstract
Obesity and diabetes mellitus are interrelated metabolic diseases involving various complex biological pathways. Pirdot leaves (Saurauia vulcani Korth.) are known to contain bioactive compounds with potential as natural antidiabetic and anti-obesity therapies. This study aimed to evaluate the potential of active compounds from pirdot leaves using an insilico approach. The study was conducted using drug-likeness analysis, ADMET prediction, toxicity prediction, network pharmacology, and molecular docking. The active compounds were analyzed using PASS Online, SwissADME, ProTox-III, Cytoscape, AutoDock Vina, and Discovery Studio Visualizer. Six active compounds, namely corosolic acid, genistein, maslinic acid, oleanolic acid, ursolic acid, and β-sitosterol, fulfilled Lipinski’s Rule of Five parameters and showed good ADMET profiles with relatively low toxicity. Network pharmacology analysis identified 427 target proteins related to diabetes and 54 target proteins related to obesity. PPI and KEGG analyses identified AKT1 as the main target for diabetes and EGFR as the main target for obesity. Molecular docking results showed that genistein had the best affinity toward AKT1 (-7.8 kcal/mol), while corosolic acid showed the best affinity toward EGFR (-9.9 kcal/mol). Ligand–protein interactions were dominated by hydrogen and hydrophobic bonds at important residues within the protein active site. Active compounds from pirdot leaves have potential as multitarget therapeutic candidates against diabetes and obesity through an insilico approach, particularly genistein and corosolic acid. However, further validation through in vitro and in vivo studies is still required.
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Copyright (c) 2026 Syukur Berkat Waruwu, Shaghira Tawarniate, Sri Dewi Kumala, Andre Prayoga, Fridelly Mairani, Christica Ilsana Surbakti, Denny Satria
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